Motif ID: SOX{8,9,10}.p2

Z-value: 1.434


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_367098140.391.4e-01Click!
SOX9chr17_+_676287720.342.0e-01Click!
SOX8chr16_+_9720640.233.9e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_128883125 2.061 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr9_+_123501186 1.387 DAB2IP
DAB2 interacting protein
chr2_-_239987557 1.240 NM_006037
 HDAC4
histone deacetylase 4
chr2_+_101680594 1.193 NM_004834
NM_145686
NM_145687
 MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr7_-_27171673 1.116 NM_152739
 HOXA9
homeobox A9
chr11_+_20005704 1.079 NAV2
neuron navigator 2
chr3_-_187309442 1.039 NM_004454
 ETV5
ets variant 5
chr10_-_97311084 1.035 NM_015385
NM_024991
 SORBS1

sorbin and SH3 domain containing 1

chr7_-_27171648 1.024 HOXA9
homeobox A9
chr20_-_17610828 1.010 NM_001042576
NM_004587
 RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr7_-_27171600 0.998 HOXA9
homeobox A9
chr6_-_11340886 0.958 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_239987629 0.942 HDAC4
histone deacetylase 4
chr17_-_46479127 0.911 SPAG9
sperm associated antigen 9
chr4_-_186969041 0.901 NM_001145672
 SORBS2
sorbin and SH3 domain containing 2
chr4_-_40631397 0.892 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr12_+_52665196 0.874 NM_017409
 HOXC10
homeobox C10
chr20_-_17610704 0.856 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr3_-_48445719 0.854 NM_002673
 PLXNB1
plexin B1
chr6_-_11340869 0.852 NEDD9
neural precursor cell expressed, developmentally down-regulated 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
4.05 4.00e-02 GO:0010811 positive regulation of cell-substrate adhesion
2.14 4.76e-02 GO:0030155 regulation of cell adhesion
2.02 1.29e-03 GO:0030029 actin filament-based process
2.01 2.61e-04 GO:0007411 axon guidance
1.99 1.32e-02 GO:0030036 actin cytoskeleton organization
1.92 1.10e-04 GO:0007409 axonogenesis
1.85 4.70e-04 GO:0048812 neuron projection morphogenesis
1.85 4.88e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.85 2.74e-03 GO:0007264 small GTPase mediated signal transduction
1.80 4.23e-04 GO:0048858 cell projection morphogenesis
1.80 1.29e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.78 6.17e-04 GO:0032990 cell part morphogenesis
1.75 2.37e-03 GO:0000904 cell morphogenesis involved in differentiation
1.72 5.86e-03 GO:0031175 neuron projection development
1.67 2.84e-03 GO:0000902 cell morphogenesis
1.65 2.55e-03 GO:0032989 cellular component morphogenesis
1.63 4.74e-03 GO:0030030 cell projection organization
1.58 6.24e-04 GO:0048699 generation of neurons
1.57 1.73e-02 GO:0030182 neuron differentiation
1.55 1.01e-02 GO:0007155 cell adhesion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
5.91 2.05e-02 GO:0043034 costamere
2.92 4.64e-02 GO:0031983 vesicle lumen
2.80 4.96e-02 GO:0031091 platelet alpha granule
2.48 3.27e-02 GO:0043296 apical junction complex
2.35 1.85e-02 GO:0030055 cell-substrate junction
2.16 5.78e-04 GO:0005911 cell-cell junction
2.15 4.82e-03 GO:0070161 anchoring junction
2.11 2.22e-02 GO:0005912 adherens junction
2.10 5.08e-03 GO:0031252 cell leading edge
1.77 2.15e-02 GO:0015629 actin cytoskeleton
1.75 3.59e-02 GO:0005874 microtubule
1.67 1.87e-04 GO:0030054 cell junction
1.43 3.34e-05 GO:0005856 cytoskeleton
1.37 3.99e-02 GO:0044430 cytoskeletal part
1.23 1.71e-02 GO:0043228 non-membrane-bounded organelle
1.23 1.71e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.18 1.16e-04 GO:0005634 nucleus
1.12 5.00e-06 GO:0043229 intracellular organelle
1.12 5.91e-06 GO:0043226 organelle
1.12 5.12e-04 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.83 4.21e-03 GO:0003779 actin binding
1.82 5.89e-06 GO:0008092 cytoskeletal protein binding
1.57 8.16e-04 GO:0019899 enzyme binding
1.52 2.29e-04 GO:0001071 nucleic acid binding transcription factor activity
1.52 2.29e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.26 1.99e-02 GO:0003677 DNA binding
1.15 5.61e-05 GO:0005515 protein binding
1.08 1.57e-04 GO:0005488 binding